This book contains manuscripts presented at the 13^th Latin American Regional Conference and 5^th Pan American Regional Conference ISME 2021, held in August 2021. The conference was virtually hosted by Universidad del Caribe and the Ministry of Education in Quintana Roo, Mexico. This compilation includes a wide range of topics in music teaching and learning, across different educational contexts, and represents the contribution of music educators and scholars from 15 countries in the American Continent. Completed papers were fully refereed by the members of the Scientific Committee before inclusion in the conference proceedings.